Author ORCID Identifier
0009-0000-1264-8718
Biosketch
Reicha holds an integrated M.Sc. degree from Central University of Jharkhand (2012-2017) and has gained research experience as a Project Assistant at the CSIR-Central Institute of Mining and Fuel Research from November 2018 to February 2021. During her tenure as a Project Assistant (Level II), she was involved in “Coal Quality Assessment”, precise data collection, and documentation of project records. Subsequently, she pursued her doctoral studies at SASTRA Deemed University from 2021 to 2026. She completed her PhD in organic chemistry at SASTRA Deemed University in 2026. During her PhD, she developed expertise in synthetic organic chemistry, particularly heterocyclic synthesis via sustainable synthetic methodologies. She also served as a teaching assistant, conducting laboratory sessions for B.Tech and M.Sc. students. As part of her academic contributions, she has authored three research articles, and two of her manuscripts are currently under preparation, focusing on sustainable methods for synthesising O- and N-heterocycles. These works demonstrate the breadth and depth of her research expertise in organic synthesis.
Date of Award
27-1-2026
Document Type
Thesis
School
School of Chemical & Biotechnology
Programme
Ph.D.-Doctoral of Philosophy
First Advisor
Dr.Y.B.R.D. Rajesh
Keywords
Organic, Synthesis, Heterocyclic, Pyrimidine, Acridine, Benzochromene, Alpha-Keto Amide, Pyrrole, Metal Free, Environmentally Friendly, Catalyst Free
Abstract
Heterocyclic compound is a significant domain of organic chemistry that focuses with synthetic, design and characteristics. This molecule is characterized by ring structure including one or more atom of an elements other than carbon (C), typically nitrogen (N), Oxygen (O) or Sulphur (S). The synthesis of heterocyclic compound via sustainable strategy encompasses various approaches such as design and implementation of real time analysis aimed at pollution prevention. It demonstrates wide range of medicinal application by showing various activities such as anticancer, anti-inflammatory, anti-microbial and many more. Additionally, many functional materials including dye, polymers etc. are the other application of heterocyclic compounds.
Chapter 1 discussion focuses on fundamental principles for sustainable synthesis of heterocyclic compounds. It also emphasizes on the importance of MCR reaction and it’s interrelation with heterocyclic synthesis. Furthermore, it outlines the relevance of cross coupling and cross dehydrogenative coupling reaction and its relevance in fused heterocyclic compounds synthesis, along with some summary of report methodologies of heterocyclic compound synthesis containing N, O, S.
Chapter 2 reports sustainable synthesis of 1,8-dioxodecahydroacridines and investigation of their photophysical properties. Acridine derivatives have become promising candidates for cancer treatment and therapies for neurodegenerative diseases, inflammatory conditions, and protozoal infections. The adopted method was TBHP mediated reaction in the presence of H2O as a solvent at 75 oC, using molecular oxygen.
Chapter 3 details about base-promoted synthesis of pyrimidines via benzyl alcohols/methyl arenes with phenyl acetylene and guanidine. And synthesis of triazine via benzyl alcohol and benzamidine. Pyrimidine has been extensively studied due to its inherent role in vitamins, nucleic acids and in various therapeutic industries, pyrimidine has been reported to have anticancer, antiparasitic, antituberculosis and many more. The triazine is intensively studied due to its widespread application in pharmaceutical, textile, plastic, and rubber industries. The established method in this chapter was initiated by deprotonation of benzyl alcohol by tBuOK.
Chapter 4 outlines solvent and metal-free approach synthesis of pyrrolidine-2-ones. Pyrrolidine-2-ones are uniquely significant for various medicinal applications, including anti-bacterial, anti-biotic, anti-tumour and cytotoxic effects. In this chapter, we intend to use phenyl glyoxalic acids instead of unstable benzaldehydes to introduce our new methodology of pyrrolidine-2-ones under metal-free conditions with the help of 20 mol% of oxalic acid as an additive.
Chapter 5 illustrates about base promoted one pot synthesis of (1H-benzochromen-2-yl)(phenyl)methanones. Chromene, commonly bearing a fused pyran ring, exists in many plants. Furthermore, they are also active in drug-resistant cancer cell lines, including multidrug-resistant tumour cells. In the reported chapter, we have talked about synthesis of (1H-benzochromen-2-yl)(phenyl)methanones, by combining β-naphthol with formaldehyde using NaOH in a mixture of 1,4-dioxane and H2O (1:1) at room temperature.
Chapter 6 represents KSCN promoted synthesis of α-ketoamides from phenyl glyoxal via cascade amidation reaction at room temperature. α-ketoamides and their derivatives are key components for various biological activities such as anti-viral, anti-HIV, anti-tumour, and anti-inflammatory effects. The synthesis was carried out using phenyl glyoxal with cyclic amine both primary and secondary in the presence of 2:1 ratio of CH3CN:H2O at room temperature. α-ketoamide under mild acidic conditions (promoter KSCN) was developed.
Recommended Citation
Pandey, Reicha Ms, "Metal Free Multicomponent C-C and C-N Bond Formation via Cross – Coupling and Cross – Dehydrogenative Coupling Methodologies for the Synthesis of Diversely Functionalized N – and O – Heterocyclic Compounds" (2026). Theses and Dissertations. 201.
https://knowledgeconnect.sastra.edu/theses/201